INDUCED PLURIPOTENT STEM CELL-DERIVED MESENCHYMAL STEM CELLS DELIVER EXOGENOUS MIR-105-5P VIA SMALL EXTRACELLULAR VESICLES TO REJUVENATE SENESCENT NUCLEUS PULPOSUS CELLS AND ATTENUATE INTERVERTEBRAL DISC DEGENERATION

Abstract Background Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have emerged as a promising new therapeutic strategy for intervertebral disc degeneration (IVDD).However, the drawbacks of MSCs, including their invasive access, the donor age, and their limited proliferative capacity, hinder the quantity and quality of MSC-sE

The development of medicine and new technologies allows for more Eye Gel effective disease diagnosis and early treatment.Life time was significantly extended for both men and women.Society in Poland and other European countries is aging.The number of people in working age is declining, while the proportion of the oldest age groups is increasing.The

Abstract Medical images occupy the largest part of the existing medical information and dealing with them is challenging not only in terms of management but also in terms of interpretation and analysis.Hence, analyzing, understanding, and classifying them, becomes a very expensive and time-consuming task, especially if performed manually.Deep learn

Masumi G Asahi,1 Andrew T Chon,1 Esmeralda Gallemore,1 Ron P Gallemore1,2 1Clinical Research Department, Retina Macula Institute, Torrance, CA, USA; 2Jules Stein Eye Institute, University of California, Los Angeles, CA, USA Purpose: To determine whether combination photodynamic therapy (PDT) and antivascular endothelial growth factor (VEGF) therapy